Why does citrated blood not coagulate

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Progress in Agricultural Engineering Sciences. Investigation of the effect of trisodium-citrate on blood coagulation by viscometric approach. Open access. A sample of the patient's blood is obtained by venipuncture. The blood is decalcified by collecting it into a tube with oxalate or citrate ions to prevent the clotting process from starting before the test. The blood cells are separated from the liquid part of blood plasma by centrifugation. The PT test is performed by adding the patient's plasma to some source of Tissue Factor e.

Calcium chloride excess quantities of ionized calcium is added to the mixture in order to counteract the sodium citrate and allow clotting to start. The test is timed from the addition of the calcium chloride until the plasma clots. This time is called the Prothrombin Time. The prothrombin test specifically evaluates the presence of factors VII, V, and X, prothrombin, and fibrinogen.

A prothrombin time within the 11 second range depends on the source of thromboplastin used indicates that the patient has normal amounts of the above clotting factors. A prolonged prothrombin time indicates a deficiency in any of factors VII, X, V, prothrombin, or fibrinogen.

It may mean that the patient has a vitamin K deficiency vitamin K is a co-factor in the synthesis of functional factors II prothrombin , VII, IX and X or a liver disease the liver is the site of synthesis of the plasma protein factors.

The prothrombin time of patients receiving a vitamin K-competing coumarin drug such as warfarin anticoagulation therapy used in deep venous thrombophlebitis will also be prolonged, usually in the range of one and one half to two times the normal PT time. Activated Partial Thromboplastin Time test The activated partial thromboplastin time aPTT is a test performed to investigate bleeding disorders and to monitor patients taking an anticlotting drug such as heparin which inhibits factors X and thrombin, while activating anti-thrombin.

The aPTT test uses blood which is decalcified to prevent clotting before the test begins. Our website uses cookies to enhance your experience.

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